Кафедра медичної та біологічної фізики і медичної інформатики
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Item New Conceptual Interpretations of Mechanisms for the Repair of DoubleStrand DNA Breaks and Their Mathematical Modeling(2020) Bondarenko, Maryna; Knigavko, Volodymyr; Zaytseva, Olga; Nikonov, Andrii; Kovalenko, GannaItem Medical informatics : tutorial for foreign English-speaking students(2019-10) Knigavko, Volodymyr; Zaytseva, Olga; Bondarenko, Maryna; Batyuk, Liliya; Rukin, AlekseyThe tutorial was created in accordance with the updated working curriculum of the discipline "Medical Informatics". The structure of the tutorial suggests the possibility of its use in practical classes in this discipline. The manual is adapted for foreign students of medical universities studying in English.Item Mathematical modeling of the processes of formation of single-stranded damages of large size and their transformation into double-stranded discontinuities of cellular DNA(2019-09-30) Knigavko, Volodymyr; Batyuk, Liliya; Zaytseva, Olga; Bondarenko, Maryna; Ponomarenko, Natalya; Rukin, AlekseiThe theoretical investigation was shown that single-strand breaks are repaired by the mechanism of ultrafast reparations, and a significant number of them are repaired during irradiation, depending on the dose rate.Item The mathematical modeling of the quantitative relationship between increasing the survival rate of oncological patients and the growth of cancer morbidity(2019-06-18) Knigavko, Volodymyr; Batyuk, Liliya; Zaytseva, Olga; Bondarenko, MarynaIt is considered that malignancy of cells requires damage to a certain number of certain genes. In the experiment, a formula is obtained that allows us to calculate the mean value of the time of occurrence in an individual oncologic disease in the initial presence in the genotype of the individual a-genes. Obviously, due to the randomness of the mutation process, the initial number of these genes in the genotypes of different people is different.Item Development of medical information science competences for English-speaking foreign students at the Department of Medical and Biological Physics and Medical Informatics(Dnipro National University, 2019-03-29) Knigavko, Volodymyr; Zaytseva, O.; Bondarenko, Maryna; Rukin, O.; Ponomarenko, N.; Batyuk, Liliya; Morozova, O.At the Department of Medical and Biological Physics and Medical Informatics of the Kharkiv National Medical University the discipline "Medical Informatics" is taught to English-speaking foreign students (over 1000 students), as well as to the state language students, on the second year. Recently, the department reoriented the teaching methodology from a knowledge-based approach to a competence (knowledge-based plus practical skills) one, that is a condition of modernization and bringing its results in accordance to international standards. Competence approach not only makes the student aware, but also determines the development of skills to solve problems that arise in real situations. Earlier in the department this discipline was taught exclusively in the form of seminars. Currently, students' training is carried out in four computer classrooms in the form of computer practical works.Item Mathematical modeling of oxygen effect under irradiation of cell DNA with X-rays or gamma radiation(2017-02) Knigavko, Volodymyr; Trofymenko, Sergey; Ponomarenko, Nataliya; Zaytseva, Olga; Bondarenko, MarynaOxygen effect is a one of the most famous and important radiobiological effects. There is a large number of experimental data reflecting one or another aspect of this effect now. However, there is not yet developed a convincing mathematical model of the oxygen effect. Thus, the creation of a mathematical model of the oxygen effect is an important step in the study of this phenomenon (effect). t should immediately be noted that the degree of oxygen effect depends on the type of radiation used in the irradiation, and this is due to the fact that the mechanisms of radiation damage vary considerably for different types of radiation. Also significantly different mechanisms of this effect are in vivo and vitro. The oxygen effect is the most strongly manifested in the irradiation of biological objects by X-ray or gamma radiation, which is the reason for this phenomenon was modeling for the above types of radiation. The purpose of the modeling in submitted study is to determine the character of the functional dependence of the number of DNA radiation breaks on the radiation dose and on the oxygen concentration in the irradiated medium containing living eukaryotic cells. Obtained in modeling results allow to propose a mathematical model of the oxygen effect, based on the known experimental data concerning nature of the oxygen effect.Item The Generalised Mutation Theory of Oncogenesis(2018-11) Knigavko, Volodymyr; Bondarenko, Maryna; Zaytseva, OlgaSeveral theories of oncogenesis are known at present, the most accepted of which is the mutational theory. However, none of the theories explain the whole set of phenomena associated with the initiation and development of cancer. The aim of the review was to try to develop a consistent theory of oncogenesis which generalises and supplements some of the already known concepts of the essence of malignization processes in cells with the new developments by the authors in the field of oncogenesis. It was concluded that the evolutionary aspect of oncogenesis allows to find out the causes of biochemical changes in a malignant cell as well as the nature of chromomeres and their functions in oncogenesis. Among the most important results of the proposed review are the suggestions on the role of evolutionary factors, the role of the genome instability of the malignant cells and the role of chromomeres in these cells.Item Medical and Biological Physics : lectures(2018-11-22) Knigavko, Volodymyr; Zaytseva, Olga; Bondarenko, Maryna; Batyuk, LiliyaAchievements in modern medicine are substantially linked to progress in biophysics, cybernetics, informatics and medical electronics. Medical and biological physics methods are a basis for developing new techniques in diagnostics and treatment. These methods are being widely introduced into the practice of research laboratories because, in many cases, understanding of the origin of diseases is based on identifying their biophysical mechanisms. This explains the necessity for students of medical universities to study the basic concepts of medical and biological physics.Item Medical information science. Рart 2(2017) Бондаренко, Марина Анатоліївна; Висоцька, Олена Володимірівна; Гордієнко, Ніна Олександрівна; Bondarenko, Maryna; Vysotskaja, E.; Gordienko, Nina; Zaitzeva, О.; Kocharova, Tetiana; Knigavko, Volodymyr; Lad, Svetlana; Meshcheriakova, O.; Polyotova, N.; Radzishevkaysa, E.; Risovanaya, L.; Shuba, I.; Solodovnikov, A.Item Medical information science. Рart 1(2017) Бондаренко, Марина Анатоліївна; Висоцька, Олена Володимірівна; Гордієнко, Ніна Олександрівна; Bondarenko, Maryna; Vysotskaja, E.; Gordienko, Nina; Zaitzeva, О.; Kocharova, Tetiana; Knigavko, Volodymyr; Lad, Svetlana; Meshcheriakova, O.; Polyotova, N.; Radzishevskaya, E.; Risovanaya, L.; Solodovnikov, A.; Shuba, I.
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