Кафедра загальної практики – сімейної медицини та внутрішніх хвороб
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Item Organ-protective effects of the alternative renin-angiotensin system and prospects for therapeutic treatment. Review(2024) Kovalyova, Olga; Ковальова, Ольга Миколаївна; Ivanchenko, Svitlana; Іванченко, Світлана Володимирівна; Zhuravlyova, Anna; Журавльова, Анна Костянтинівна; Shapkin, Vadym; Шапкін, Вадим ЄвгеновичThe article is devoted to review the data regarding the identification of biochemical and functional features of the components of the renin-angiotensin system using the tools of bibliometric analysis of scientific literature. A modern interpretation by the dividing of the multifunctional complex into two systems, namely the classical renin-angiotensin system and alternative renin-angiotensin system, in accordance with the definition of biological effects, is given. The enzymatic cascade involved in the production and metabolism of peptides in both classical and non-classical pathways of renin-angiotensin systems is shown from the point of view of the evolution of scientific concepts. The triggering role of components of the classical renin-angiotensin system in pathophysiological processes with transformation into cardiovascular diseases and metabolic dysfunction has been proven. The history of the creation of pharmacological drugs for the correction of the classic renin-angiotensin system is presented. In view of the achievement of recent years, the revision of the alternative renin-angiotensin system is emphasized due to the discovery of the counter-regulatory action of the angiotensin-converting enzyme 2, angiotensin-(1 — 7), the Mas receptor in relation to their correction of metabolic processes, regulation of blood pressure, and the presence of anti-fibrotic, anti-inflammatory and antioxidant properties. The positive effect of the components of the non-classical renin-angiotensin system on the protection of the cardiovascular system and kidney is presented based on the results of experimental studies on animals. Pharmacokinetic and pharmacodynamics characteristics of recombinant angiotensin-converting enzyme 2 in experiments on healthy volunteers are highlighted. The potential protective effects of angiotensin-converting enzyme 2 and angiotensin-(1 — 7) concerning cardiometabolic risk are presented. The available data indicate the need for further comprehensive scientific investigations of the components of alternative renin-angiotensin system to create a new class of pharmacological agents with their implementation in medical practice.Item The organization of the healthcare system in Morocco focus on the roles of the family doctor(sci-conf.com.ua, 2024-11-11) Ivanchenko, Svitlana; Іванченко, Світлана Володимирівна; Hiba, NjimiThe health care system is a multi-level functional managed system that is created and used by society to implement the entire complex of social and medical measures aimed at protecting and strengthening the health of each person and the population of the country as a whole. In Morocco, the organization of the healthcare system is based on several foundational principles aimed at providing accessible, affordable, and quality care to all citizens.Item Cell death in human pathology(2024) Kovalyova, Olga; Ковальова, Ольга Миколаївна; Shapkin, Vadym; Шапкін, Вадим Євгенович; Ivanchenko, Svitlana; Іванченко, Світлана ВолодимирівнаAn analytical review of the present article is devoted to the aspects of cell death with emphasis on biochemical, morphological, molecular and cellular mechanisms its development, modulation and progression. The triggers of apoptosis, necrosis, necroptosis, pyroptosis, and autophagy are described. The pathogenetic pathway of the relationship between the inflammatory stimuli, programmed cell death, and immune response are considered. Ferroptosis as a novel type of regulated cell death is presented. The contribution of inflammasomes that promote inflammation by activating the caspase-1 in pyroptosis is shown. The article is focused on the role of the autophagy in age-related and neurodegenerative diseases, its impact on the resistance during anticancer therapy. A promising approach aimed at solving specific problems of numerous diseases with cell death involvement and translation appropriated knowledge in clinical practice is emphasized.