Cell death in human pathology

Abstract

An analytical review of the present article is devoted to the aspects of cell death with emphasis on biochemical, morphological, molecular and cellular mechanisms its development, modulation and progression. The triggers of apoptosis, necrosis, necroptosis, pyroptosis, and autophagy are described. The pathogenetic pathway of the relationship between the inflammatory stimuli, programmed cell death, and immune response are considered. Ferroptosis as a novel type of regulated cell death is presented. The contribution of inflammasomes that promote inflammation by activating the caspase-1 in pyroptosis is shown. The article is focused on the role of the autophagy in age-related and neurodegenerative diseases, its impact on the resistance during anticancer therapy. A promising approach aimed at solving specific problems of numerous diseases with cell death involvement and translation appropriated knowledge in clinical practice is emphasized.