Наукові праці. Кафедра акушерства та гінекології № 3

Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/31733

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    Gestational trophoblastic diseases-diagnosis and risk factors: A case series
    (ScopeMed Publishing, 2019-07-04) Uzel, Kemine; Basol, Gulfem; Kale, Ahmet; Lakhno, Igor
    Aim of study: The aim of our study is to investigate the role of the age, gravida, parity, blood group in the development of GTD also significance of the b-hCG levels and pelvic ultrasonography in diagnosis and treatment of this patients. Comparisons of GTD incidence between Turkey and different regions of the world. Materials and Metods: This retrospective study included 1813 patients which underwent vacuum aspiration from 2010 to2018 years in Derince Training and Research Hospital, Kocaeli, Turkey. Files of 18 patients compatible with GTD in pathology were retrospectively scanned. Result: As a result of the study, the average age of patients were27.06, pathology results were found in 14 patients (77,7%) partial mol, in 2 patients (11,1%) complete mol, invasive mol in 1 patient (5,6%) and choriocarcinoma in 1 patient (5,6%). In these cases, 1 case of lung metastasis and 3 patients received chemotherapy treatment. There was no mortality associated with the disease during follow-up. Conclusion: The calculated GTD incidence was 1,5 per 1000 births. Radiologist plays a main role in the first diagnosis of GTD and basis disease management and early finding of its complications. Although serum b- hCG is a useful biochemical marker for GTD. Ultrasound is the initial line radiological examination in approving the diagnosis of GTD in a case suspected on the basis of clinical detections and b- hCG levels. We believe that diagnosis, adequate treatment and follow-up will make easy the cure of GTD and the incidence can be calculated more exacly by performing wide community-based studies.
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    Tocilizumab is effective in preventing ovarian injury induced by ischemia- reperfusion in rats
    (Academia Brasileira de Ciências, 2023-05-15) Uzel, Kemine; Lakhno, Igor; Turkler, Can; Kuzucu, Mehmet; Naz, Gulce Yazici; Mammadov, Renad; Suleyman, Bahadir Ahadir; Kale, Ahmet; Suleyman, Halis
    Ovarian torsion can be defined as the bending of the ovaries on the supporting ligament, disrupting both venous and arterial blood circulation. Insufficient blood flow causes ovarian tissue hypoxia and leads to ischemia. This study aimed to investigate whether tocilizumab has a protective effect on ischemia-reperfusion injury due to ovarian torsion in rats. Eighteen female Wistar albino rats were divided into three equal groups (Sham (SG), ischemia-reperfusion (OIR), and ischemia-reperfusion+tocilizumab (OIRT)). Degeneration, necrosis, vascular dilatation/congestion, interstitial edema, hemorrhage, and polymorphonuclear lymphocyte (PMNL) infiltration scores were significantly different between the groups (p=0.001 for all parameters). Moreover, the OIRT group had a significant improvement in these criteria compared to the OIR group (p<0.05). Additionally, there was a considerable difference between OIRT and OIR groups in the number of primordial, developing, and atretic follicles groups (p<0.05), while there was no difference in the number of corpus luteum (p=0.052). Stress markers or cytokines, such as MDA, tGSH, NF-κB, TNF-α, IL-1β, and IL-6, were significantly different between groups (p<0.05). Furthermore, a significant improvement was found in the measured variables when the OIRT group was compared with the OIR group (p<0.05). Tocilizumab may be an alternative option for treating ischemia-reperfusion injury due to ovarian torsion.