Кафедра педіатрії № 1 та неонатології
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Item Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Macimorelin in Children with Suspected Growth Hormone Deficiency : An Open-Label, Group Comparison, Dose-Escalation Trial(2021) Csаkvаry, Violetta; Ammer, Nicola; Bagci, Ekaterine; Bolshova, Olena; Damholt, Birgitte Bentz; Katanic, Dragan; Mikhailova, Evgenia; Muzsnai, Ágota; Radu, Dmitri; Senatorova, Ganna; Szalecki, Mieczysław; Teifel, Michael; Vajda, Zsolt; Zelinska, Nataliya; Chaychenko, TetyanaDiagnosis of growth hormone deficiency (GHD) in children requires the use of provocative growth hormone (GH) stimulation tests, which can have limited reliability and are potentially contraindicated in some patients. This is the first paediatric study to test the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of macimorelin, an oral GH secretagogue, approved for diagnosis of adult GHD. Methods: In this open-label, group com parison, single-dose escalation trial (EudraCT 2018-00198823), sequential cohorts of patients (C1–C3) received ascending single doses of macimorelin: 0.25 (C1), 0.5 (C2), and 1.0 (C3) mg/kg. Primary endpoints were safety and tolerability, and secondary endpoints were PK/PD. Results: Twenty-four patients aged between 2 and <18 with suspected GHD participated in the study. No macimorelin-related adverse events were reported, and macimorelin was well tolerated.Item Variants of hyperlipidemia in obese children are gender and insulin resistance dependent(2020) Chaychenko, Tetyana; Kharkovа, M.; Rybka, О.Item Pharmacokinetics and pharmacodynamics of macimorelin acetate (EZS-130) in paediatric patients with suspected growth hormone deficiency (GHD)(2020) Csákváry, V.; Muzsnai, A.; Raduk, D.; Chaychenko, Tetyana; Damholt, B.; Bagci, E.; Teifel, M.; Ammer, N.Item Variants of hyperlipidemia in obese children are gender and insulin resistance dependent(2020) Chaychenko, Tetyana; Kharkovа, M.; Rybka, О.Item Variants of hyperlipidemia in children with insulin resistance(2020) Chaychenko, Tetyana; Kharkovа, M.; Rybka, O.Obesity in adults and children is characterized by epidemiological prevalence with a tendency to increase. The purpose of the study was to analyze the lipid profile in overweight children, depending on the presence of insulin resistance. 247 overweight and obese children aged 2 to 18 were examined, including 160 boys and 87 girls. Obesity was diagnosed if the BMI exceeded 97 percentile, according to gender and age. Assessment of the lipid profile included measurements of total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein. To evaluate the parameters of the lipid profile, we used the National Cholesterol Education Program (NCEP) according to the latest edition (2006). Lipid values depending on the presence or absence of insulin resistance were analyzed. BMI was also evaluated according to Z-BMI. Insulin resistance was detected in 69.9% of children. Hyperlipidemia was detected in 24.9% of children and dyslipidemia in 83% of the children examined. A change was found in all indicators of the lipid profile, depending on the presence of insulin resistance. A significant increase in Z-BMI was revealed depending on the presence of insulin resistance. Conclusions: the majority of overweight children have insulin resistance and dyslipidemia; the type of dyslipidemia in children with obesity directly depends on the presence of insulin resistance.Item Associations between lipid parameters and insulin resistance in obese adolescents(2019) Chaychenko, Tetyana; Kharkovа, M.; Rybka, О.Item Analysis of the relationship of lipid profile and сarbohydrate metabolism in obese children(2019) Kharkovа, M.; Rybka, O.; Chaychenko, TetyanaItem School-age children awareness of the causes of obesity and its health related outcomes(2019) Chaychenko, Tetyana; Gonchar, Margaryta; Chumachenko, Tetyana; Klymenko, Viktoriia; Samsonenko, T.; Kharkovа, M.; Гончарь, M.A.; Чайченко, Т.В.; Харькова, М.О.Childhood obesity is a serious medical condition affecting children and adolescents that can be prevented by life style modification. Therefore, school-age children awareness of the causes of obesity and its health related outcomes is very importan. Subjects Methods This work is a part of the complex project "Assessment of the current nutritional status, nutritionrelated health problems in school-age children in Ukraine". The total number of participants is 392 school-age children who were grouped by the age: primary school (75 children aged 6–9), secondary school (202 children aged 10–14) and high school (115 children aged 15–18). Original questionnaire was elaborated for the survey, consisting of both multiple choice questions and "open questions" that encouraged children to give their own idea with the purpose of understanding a real awareness of the problem. Answers to the open questions about the causes and effects of obesity were assessed. Results One third of respondents regardless of age (primary school, – 29.31%, secondary school – 29.21%, high school – 33.04%, p>0.05) understood that obesity can cause serious health problems and the most detrimental changes can occur in the cardiovascular system. It was established that selfcontrolled situations were named as the main causatives of the obesity by more than half of surveyed children (53.33% of primary school, 53.46% of secondary school children and 41.74% high school children, p>0.05). We established that less than 10% of children were not aware of the causes of obesity and possible outcomes. Meantime, 30% of respondents were not prone to give any answer. Conclusions: Regardless of age school-children are aware of health-related problems caused by obesity. Special education programs are necessary for all school-age children with the purpose of developing the responsibility for the health in their adult life.Item Nutritional rickets in children (case report)(2019) Chaychenko, Tetyana; Shulha, N.; Kharkovа, M.; Rybka, O.; Buzhinska, Nadiya; Chercun, A.; Чайченко, Т.В; Рибка, О.С.; Харькова, М.О.; Бужинська, Н.Р.Nutritional rickets (NR) caused by vitamin D and/or dietary calcium deficiency remains a significant global, public health problem. The main causes of NR are discussed with a focus on the investigations, management and prophylaxis by the Global Consensus Recommendations on Prevention and Management of NR (2016). The article presents a clinical case of NR in a girl aged 4 years and 3 months admitted to our hospital with severe deformation of low extremities. She was found to have vitamin D-deficient state with extremely high alkaline phosphatase, suggestive for massive bone resorption. NR was diagnosed following comprehensive examination and therapy according to the protocol was initiated. Conclusions: NR rate tends to the incline in both low-income and industrialized countries, which requires special attention of pediatricians to the classical clinical presentation with particular focus on the risk group.Item Шляхи попередження ожиріння за уявленнями дітей шкільного віку(2019) Чайченко, Т.В.; Самсонова, Т.В.; Гончарь, М.О.; Чумаченко, Т.О.; Кліменко, В.А.; Рибка, О.С.; Бужинська, Н.Р.; Gonchar, Margaryta; Chaychenko, Tetyana; Rybka, O.