Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки
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Item Antihypertensive treatment effects on systemic inflammation, oxidative stress and proinflammatory cytokines(2020-12) Ashcheulova, Tetyana; Gerasimchuk, Nina; Kovalyova, Olga; Kompaniiets, Kira; Honchar, OleksiiHypertension in its origin is a heterogeneous and multisystemic disease. Evaluatation of the oxidative stress activity based on the level of 8-iso-PgF2α, of proinflammatory cytokines based on tumor necrosis factor-α and its type I soluble receptor and C-reactive protein is relevant for further understanding of pathogenesis of hypertension and improvement of the early diagnostics of heart failure.186 hypertensive patients have been observed during the 2-months course of treatment, aged 30 to 65 years. The serum levels of 8-iso-PgF2α (n = 34), tumor necrosis factor-α and its type I soluble receptor were determined by ELISA before and after course of treatment. C-reactive protein level was determined by biochemical method. The control group included 16 practically healthy individuals, aged 27 to 55 years. Hypertensive patients enrolled into study had been randomized into 3 arms that received different protocols of combined anti-hypertensive therapy. I clinical group – а combination of a bisoprolol and indapamid, II – а combination of a lacidipine and candesartan, III – а combination of а fosinopril sodium and hydrochlorothiazide. On the background of combined antihypertensive therapy, we observed favorable dynamics of 8-iso-PgF2α, tumor necrosis factor-α and its type I soluble receptor and C-reactive protein. Taking into account the insignificance of the correlations revealed, a one-factor dispersion analysis was applied which allows to determine with certainty the influence of the grade and duration of hypertension on the dynamics of the studied indices levels. It has been found that the grade of hypertension is related to the increase in TNF-α and 8-iso-PgF2α serum levels, but not on to TNF-α type I soluble receptor, and the duration of hypertension is related to the increase in activity of the C-reactive protein, TNF-α and its type I soluble receptor, with no relation to the level of 8-iso-PgF2α. Thus, oxidative stress possibly promotes the activation of potentially damaging immune mechanisms mediated by pro-inflammatory cytokines, nonspecific inflammation and drives the further progression of the target organs lesions.Item Interleukin-22 Level and Vascular Remodeling in Patients with Hypertension in Associated with Abdominal Obesity(2019) Kysylenko, Kateryna; Kovalyova, Olga; Кисиленко, Катерина ВолодимирівнаThe purpose of the study was to estimate the interleukin-22 (IL-22) level in the blood serum of hypertensive patients with abdominal obesity (AO), depending on common carotid arteries (CCA) remodeling presence. Ninety-five subjects: 83 hypertensive patients and 12 healthy controls were examined. The patients were divided into two groups, depending on the presence of AO followed by the division of patients into subgroups depending on the intima-media thickness (IMT). For all patients, the following anthropometric parameters were measured: weight, height, waist circumstances (WC), hip circumstances (HC); the body mass index (BMI) and the waist-to-hip ratio (WC/HC) were calculated. The serum IL-22 level was determined in the patients by means of the Bender Medsystems® Human IL-22 Platinum ELISA kit by immunoassay method. Additionally, the patients underwent an ultrasound examination of carotid arteries. The study revealed that the CCA IMT in hypertensive patients with and without AO compared to the control group were significant differences. Serum IL-22 levels in hypertensive patients with AO having IMT ≥ 0.9 mm was statistically higher as compared with patients having IMT < 0.9 mm. The IL-22 levels in hypertensive patients without AO having IMT < 0.9 mm and having IMT ≥ 0.9 mm were significantly exceeds cytokine level in the control group. The obtained results may indicate that the blood serum IL-22 level is associated with a greater degree of vascular wall damage in hyprtensive patient both with and without AO. Higher IL-22 levels in the groups of hypertensive patients both with and without AO, with normal IMT compared with the control group, probably indicate that elevated blood serum IL-22 content can promote an early affection of the vascular endothelium.Item Основные методы обследования больных в клинике внутренних болезней. Часть 1 : практикум(2017) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ковальова, Ольга Миколаївна; Ковальова, Ольга Николаевна; Kovalyova, Olga; Амбросова, Тетяна Миколаївна; Амбросова, Татьяна Николаевна; Ambrosova, Tetyana; Смирнова, Виктория Ивановна; Смирнова, Вікторія Іванівна; Смирнова, Вікторія Іванівна; Смирнова, Виктория Ивановна; Smyrnova, Victoriia; Герасимчук, Ніна Миколаївна; Герасимчук, Нина Николаевна; Gerasimchuk, Nina; Sytina, Irina; Ситіна, Ірина ВасилівнаПрактикум по пропедевтике внутренней медицины. Часть 1. «Основные методы обследования больных в клинике внутренних болезней»Item Практикум з курсу "Сестринська справа у терапевтичному стаціонарі"(ХНМУ, 2018) Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ashcheulova, Tetyana; Ковальова, Ольга Миколаївна; Ковалева, Ольга Николаевна; Kovalyova, Olga; Ситіна, Ірина Василівна; Сытина, Ирина ВасильевнаItem Аналіз сечі, функціональні проби(2018) Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ashcheulova, Tetyana; Ковальова, Ольга Миколаївна; Ковалева, Ольга Николаевна; Kovalyova, Olga; Латогуз, Юрій Іванович; Латогуз, Юрий Иванович; Latohuz, JuriiItem Основні клініко-лабораторні й інструментальні методи обстеження нирок(2018) Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ashcheulova, Tetyana; Ковальова, Ольга Миколаївна; Ковалева, Ольга Николаевна; Kovalyova, Olga; Латогуз, Юрій Іванович; Латогуз, Юрий Иванович; Latohuz, JuriiItem Основні симптоми та синдроми при захворюваннях нирок – гострому та хронічному гломерулонефриті та пієлонефриті(2018) Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ashcheulova, Tetyana; Ковальова, Ольга Миколаївна; Ковалева, Ольга Николаевна; Kovalyova, Olga; Латогуз, Юрій Іванович; Латогуз, Юрий Иванович; Latohuz, JuriiItem Надбані вади серця: мітральні та аортальні(2018) Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Ashcheulova, Tetyana; Ковальова, Ольга Миколаївна; Ковальова, Ольга Николаевна; Kovalyova, Olga; Герасимчук, Ніна Миколаївна; Герасимчук, Нина Николаевна; Gerasimchuk, NinaItem Serum chemerin and renal dysfunction in hypertensive patients with obesity(2018) Гончарь, Алексей Владимирович; Гончарь, Олексій Володимирович; Honchar, Oleksii; Ковальова, Ольга Миколаївна; Ковалева, Ольга Николаевна; Kovalyova, Olga; Иванченко, Светлана Владимировна; Іванченко, Світлана Володимирівна; Ivanchenko, SvitlanaItem Left ventricular diastolic function in patients with hypertensive kidney disease and obesity(2018) Гончарь, Алексей Владимирович; Гончарь, Олексій Володимирович; Honchar, Oleksii; Ащеулова, Татьяна Вадимовна; Ащеулова, Тетяна Вадимівна; Ashcheulova, Tetyana; Kovalyova, Olga; Ковальова, Ольга Миколаївна; Ковалева, Ольга Николаевна; Амбросова, Татьяна Николаевна; Амбросова, Тетяна Миколаївна; Ambrosova, Tetyana; Matyash, Nataliia; Матяш, Наталья Михайловна; Матяш, Наталія Михайлівна