Кафедра стоматології дитячого віку та імплантології
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Item Signs of oral cavity microcirculatory disorders in adolescents who smoke(2024-08) Grygorova, A.; Grygorov, S.; Yaroslavska, Yu.; Mykhailenko, N.; Demyanyk, D.; Steblianko, A.; Rak, O.; Voloshan, O.; Nazaryan, R.Smoking is one of the most common harmful habits that can lead to the development of pathological processes in various organs and systems. At the same time, smoking in childhood and adolescence especially contributes to the deterioration of the general somatic condition, increases the risk and determines the severity of the course of respiratory diseases, which in the future has an impact on the development and functioning of the respiratory system, becomes the cause of dependent conditions and complicates the course of accompanying pathology. It is believed that disruption of the microcirculatory channel can be one of the key links in the development of pathological processes in the oral cavity. Therefore, improving the quality of diagnosis of lesions of the microcirculatory bed of periodontal tissues in the early stages of the inflammatory process became the goal of our work.Item The relationship between the condition of the oral cavity and the use of tobacco products in different age groups(2024-05) Moroka, R.; Povaliaiev, V.; Tkachenko, I.; Fomenko, Yu.; Babai, O.; Mikulinska-Rudich, Yu.; Iskorostenska, O.; Borisenko, Ye.; Nazaryan, R.; Gargin, V.Understanding the harmful effects of using tobacco products (cigarettes, electronic cigarettes (e-cigarette) or vape, IQOS, hookah, etc.) by various segments of the population is one of the important ways to improve the condition of the tissues of the oral cavity, since smoking is an important risk factor for the occurrence of chronic destructive periodontal diseases.Item Etiology, diagnosis and treatment of muscle-articular dysfunction of the temporomandibular joint in adolescence(2024-05) Yaroslavska, J.; Hrechko, N.; Vlasov, A.; Smorodskyi, V.; Storozheva, M.; Skliar, S.; Lupyr, M.; Nazaryan, R.Etiologic and pathogenetic aspects cause the most contentious issue in the study of temporomandibular joint (TMJ) syndrome in childhood and adolescence. Some researchers have linked the emergence of this group of diseases with abnormal occlusion, others have more emphasis on the age characteristics of a growing organism, or rather on a number of morphological and psychomotor processes arising and ending at puberty and cause physiological abnormalities in the growing organism.Item Self-medication practice as an alternative to treating patients who need an emergency dental care: the realities of today(ALUNA Publishing, 2024-03) Nazaryan, R.; Kuzina, V.; Tkachenko, M.; Khmiz, T.; Tkachenko, I.Dental diseases are quite common in our society. At the same time, the symptoms of dental pathology are varied. This may be a carious cavity or discoloration of the tooth, bad breath, bleeding gums, tooth mobility, calculus, soft tissue swelling, etc. Any of these conditions require professional intervention, which may be in the form of emergency or palliative care. Pain in its different manifestations is still in the first place among the complaints of dental patients. It creates discomfort and requires emergency care. In addition, this symptom is often accompanied by a certain fear of dental intervention, conscious or forced postponement of the visit as well as self-medication practice to eliminate the problem.Item Diagnostic assessment and treatment of cherubism as prevention of ocular complications(2022) Nazaryan, R.; Mikhailenko, N.; Yaroslavska, Yu.; Bondarenko, A.; Gargin, V.; Lytvynenko, M.; Artiomov, O.; Oliynyk, D.; Tregub, T.Item Importance of antimicrobial factors for microbiocenosis and local immunity of the oral cavity in children with mucoviscidosis(2022) Khmiz, T.; Tkachenko, M.; Kovalenko, N.; Bocharova, T.; Bondarenko, A.; Shevchuk, V.; Odushkina, N.; Nazaryan, R.; Gargin, V.The involvement of commensals and opportunistic pathogens and the role of protective mechanisms in the development of dental diseases in children with cystic fibrosis require more detailed study. The aim of the study was to determine the ecological characteristics of the oral microbiota and some antimicrobial factors of saliva in children with mucoviscidosis. Materials and methods. The study involved an assessment of oral microbiota as complex ecological system that protects the human body from colonization by pathogenic flora in children with cystic fibrosis. Bacteriological studies have been performed on clinical material from 30 children with mucoviscidosis diagnosed with dental and periodontal diseases. Results. In the microbiological study of plaque microbiota, 70 strains of opportunistic pathogens were isolated in patients with mucoviscidosis. The most significant were alpha-hemolytic Streptococci (40%). The proportion of bacteria of Neisseria genus in patients with cystic fibrosis was lower and amounted to 24.3%. C. albicans fungi were isolated in comparable values (18.5%), S. aureus (8.5%), as well as gram-negative strains of E. aerogenes (4.3%) and E. coli (4.3%) significantly dominated. The results indicate that opportunistic pathogens S. aureus, E. aerogenes and E. coli partially replaced the representatives of the normal oral microbiota alpha-hemolytic streptococci and non-pathogenic species of Neisseria genus in patients with mucoviscidosis. Conclusions. Microbiota of plaque in children with mucoviscidosis is characterized by an expansion of the spectrum of opportunistic pathogens due to Staphylococcus aureus, enterobacteria and C. albicans fungi, which indicates a violation of the microbiocenosis due to reduced mucosal immunity. Mucosal immunity of the oral cavity in children with mucoviscidosis is characterized by a 1.5-fold decrease in lysozyme activity and the level of secretory IgA in the saliva of children.Item Antimicrobial Activity Derivatives 2H-pirano[2,3-c]piridines against Pathogens of Intestinal Yersiniosis(Journal of Pharmacy and Nutrition Sciences, 2021) Ivannik, V.; Torianyk, I.; Moiseienko, T.; Skliar, A.; Yeromenko, R.; Hnatiuk, V.; Podrigalo, L.; Nazaryan, R.; Mikhailenko, Nina; Gargin, V.Background: An important aspect in the treatment of patients with intestinal yersiniosis is the administration of effective antibiotic therapy. Performed research aimed to determine the spectrum and level of antimicrobial activity of 2H-pyrano[2,3-c]pyridine derivatives on the museum and clinical strains of gram-negative microorganisms Yersinia enterocolitica. Methodology: The object of the study was 28 synthetic derivatives of 2H-pyrano[2,3-c]pyridine. The compounds were studied according to their chemical structure. Weused the method of serial dilutions in Muller-Hinton liquid nutrient medium with a museum’s and clinical strains of Y.enterocolitica. Results: Studies indicate the promise of further study of the properties of 2Hpyrono[2,3-c]pyridine to create an effective antimicrobial medicine. According to theresults of studies on action of antimicrobial compounds synthesized on the basis of 2H-pyrano[2,3-с]pyridine derivatives, it was found that the MIC of compounds for all Y. enterocolitica strains was 100.0 μg/ml. The MBCC of most cultures of Yersinia (72.3 %) was 200.0 μg/ml. Compound 2{3} had a pronounced antiyersiniotic activity, the inhibitory effect of which was manifested at a concentration of 25.0 μg/ml. Retarding the growth of most Yersinia strains (95.3%) with a MIC of 50.0 μg/ml, the MIC of compounds ranged from 50.0 to 200.0 μg/ml. After statistical data processing, pyridine derivatives (compounds 2{3} and 3{5}) were identified, possessing an effective bacteriostatic and bactericidal effect on Y. enterocolitica strains. Conclusions: The results of the research showed a high antimicrobial activity of 2Hpyrano[2,3-c]pyridine derivatives. The highest activity against Y. enterocolitica wasfound for 2-N2-arylimino-5-hydroxy-methyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-N1-aricarboxamide derivatives.Item The impact of smoking on the morphofunctional state of periodontal tissues of young organism(ХНМУ, 2021) Romaniuk, A.; Nazaryan, R.; Zakut, Y.; Popova, T.; Gargin, V.Background. The interrelation of disorders in periodontal tissues with metabolic changes caused, in particular, by a violation of microcirculation, observed namely in smoking but the fact that the effect of smoking on the condition of periodontal tissues at a young age has been studied less than other risk factors deserves special attention. The aim of our study was to experimentally assess the effect of smoking on the morphofunctional state of periodontal tissues in young animals. Materials and methods. Simulation of smoking has been performed with ten-week-old WAG rats using the Boyarchuck chamber. Morphometric studies were performed in the gingival zone which was chosen for morphological interpretation of volumes of specific vascular density in microcirculatory bed, specific density of connective tissue in lamina propria and specific area of tissue with ischemia. The obtained digital data were processed by the methods of variation statistics. Results. Simulation of smoking for four weeks in experimental animals leads to pathological changes in the morphofunctional state of the periodontium with reducing vascular density from 19,44±1,97% to 11,03±1,38 %, increasing area of connective tissue from 18,33±2,71% to 26,49±1,24%, spreading area of tissue with ischemia from 1,14±0,70% to 6,35±1,67%. Conclusions. Morphofunctional changes in the periodontium with damage to the structure of the epithelial membrane and changes in its permeability, microcirculatory disorders, sclerotic changes are a manifestation of the initial inflammatory and dystrophic processes that can lead to persistent chronic pathology.Item Investigation of the properties of the oral liquid and polymorphism of the muc5b gene in children with cystic fibrosis(Kharkiv National Medical University, 2020-03) Nazaryan, R.; Tkachenko, M.; Volkova, N.Item Influence of the complex treatment of chronic generalized catarrhal gingivitis on microbiological and immunological parameters of oral cavity of children with cystic fibrosis(2017-10) Nazaryan, R.; Tkachenko, M.; Kovalenko, NatalyaЗ метою попередження розвитку інфекції при хронічному генералізованому катаральному гінгівіті у дітей, хворих на муковісцидоз, запропоновано лікувально-профілактичний комплекс, який поєднує застосування гелю, що містить хлоргексидину біглюконат, амінофторид та бетаїн; суміші 12,5% розчину кислоти акридоноцтової і 0,9% розчину натрію хлориду для ротових ванночок; ультразвукової та електротерапії із засобом, що містить 0,01% розчину мірамістину. У результаті проведених лікувально-профілактичнх заходів відбувалося відновлення нормальної мікрофлори зубного нальоту за рахунок α-гемолітичних стрептококів і нейсерій, що спричинило зменшення у 1,6 рази формування асоціацій мікроорганізмів і витіснення S. aureus та зниження частки C. albicans з 18,6 % до 7,4 %. Крім того, спостерігалося збільшення продукції лізоциму та секреторного імуноглобуліну. Проте через 3 місяці знову відбулася колонізація дослідженого біотопу золотистим стафілококом, а кількість грибів C. albicans зросла до 14,7 %.