Кафедра загальної практики – сімейної медицини та внутрішніх хвороб
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Item The ethical principlesin biopharmaceutical research(ХНМУ, 2023-11-17) Kovalyova, Olga; Ковальова, Ольга Миколаїівна; Zhuravlyova, Anna; Журавльова, Анна Костянтинівна; Ivanchenko, Svitlana; Іванченко, Світлана ВолодимирівнаAn analytical review is devoted to the aspects of the biopharmaceutical ethics. The international guidelines and declarations which providing the development the effective and safety pharmaceutical healthcare products are described. The main ethical requirements on clinical drug testing are shown. The definition of bioethics concepts, principles, and rules within biomedical research with involving human subjects are considered. A promising approach aimed to widely incorporation appropriated knowledge in clinical trials is emphasized.Item The bioethical principles of the benefit-risk assessment of new drugs(НФаУ, 2023-11-16) Kovalyova, Olga; Ковальова, Ольга МиколаїівнаThe bioethical principles of the benefit-risk assessment of new drugsItem Prenatal gender selection: medical, ethical and psychological aspects(Scientific Route OÜ, 2023) Kovalyova, Olga; Ковальова, Ольга Миколаїівна; Mykytenko, Dmytro; Микитенко, Дмитро ОлександровичPrenatal gender selection: medical, ethical and psychological aspectsItem Renin-angiotensin system: a review of historical perspectives(Івано-Франківський національний медичний університет, 2023) Kovalyova, Olga; Ковальова, Ольга Миколаїівна; Zhuravlyova, Anna; Журавльова, Анна Костянтинівна; Ivanchenko, Svitlana; Іванченко, Світлана ВолодимирівнаThe article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the subsequent discoveries of angiotensin-converting enzyme 2, angiotensin-(1-7), Mas receptor. This paper presents a modern classification of the renin-angiotensin system, dividing it into classical and non-classical branches, based on the determination of the biological effects of its components. Significant attention is devoted to elucidating the biochemical cascade of the renin-angiotensin system, its physiological transformations, and its implications in human body processes. The detrimental cardiac effects of the classical renin-angiotensin system are highlighted, along with the crucial role played by its alternative axis in counteracting the development of cardiovascular diseases. The article presents data on the involvement of angiotensin-converting enzyme 2 and its receptors in coronavirus infections, susceptibility to infection, and disease progression.