Наукові праці. Кафедра загальної та клінічної патофізіології імені Д.О. Альперна
Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/1563
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Item Use of visual teaching methods to increase the level of knowledge of educators(2023) Kucheriavchenko, Maryna; Кучерявченко, Марина ОлександрівнаItem Role of risk factors in the development of endometriosis(2023) Tsinkevych, Yulia; Kuznetsova, MilenaItem Features of psycho-emotional status disorders of medical students in the conditions of full-scale war(2023) Buha, V.; Huliieva, V.; Sliusarenko, D.; Boiko, I.; Kovaltsova, M.; Myroshnychenko, M.Item The impact of external positive motivation for obtaining education among students of a medical university(2023) Myroshnychenko, Mykhailo; Kuznetsova, Milena; Bibichenko, Viktoria; Myroshnychenko, SerhiiItem Composite ceramics as a modern trend in dental medicine(2023) Gevorkyan, E.; Morozova, O.; Nerubatskyi, V.; Morozov, O.Item Ethical aspects of conducting research: point of view of medical university students(2023) Topoliuk, Kateryna; Tsymbal, Maryna; Myroshnychenko, MykhailoItem Characterization of the effect of chronic immobilization stress on the structural and functional state of the liver of mother rats and their one-month-old offspring as a risk factor for liver cancer(2023) Kuznetsova, Milena; Bibichenko, Viktoriia; Kuznetsova, Irina; Sarapulova, SnizhanaItem Reactive oxygen species generation by blood leucocytes of rats with polycystic ovary syndrome under the conditions of intermittent cold exposure(2023) Zhulikova, Maryna; Myroshnychenko, Mykhailo; Nakonechna, Oksana; Zhulikov, Oleh; Pustova, Nataliia; Bibichenko, Viktoriia; Lytvynenko, Olena; Kucheriavchenko, MarynaThe aim of this study was to determine the level of ROS production by blood leukocytes of rats with PCOS under the conditions of intermittent cold exposure. Materials and methods: In the study, 40 immature female rats of the WAG population at the age of 27 days with a body weight of 80-90 g were used. Five groups were formed (8 animals in each group). Group 1 was represented by intact rats that were not subjected to any manipulations. Group 2 was represented by rats that were injected subcutaneously with 0.2 ml of purified and sterilized olive oil daily for 25 days. Group 3 was represented by rats that were exposed to intermittent cold for 25 days. Group 4 was represented by rats that were modeled with PCOS. Group 5 was represented by rats, which were simulated PCOS against the background of intermittent cold exposure. ROS production was estimated in leukocytes isolated from rats of all groups by flow cytometry using the fluorescent probe of 2,7-dichlorodihydrofluorescein diacetate (H2DCFDA). Results: The experimental study revealed an intracellular excessive production of ROS by leukocytes in rats with polycystic ovary syndrome. The use of intermittent cold exposure normalized the production of reactive oxygen species by leukocytes in rats with polycystic ovary syndrome. Conclusions: The effectiveness of intermittent cold exposure, proven by the authors, allows recommending its use as one of the methods of prevention and treatment of the polycystic ovary syndrome.Item Scientific research in higher medical education institutions through the prism of war: ethical dimension(2023) Myroshnychenko, Mykhailo; Lazurenko, Viktoriya; Kapustnyk, Nataliia; Pasiyeshvili, Nana; Markovskyi, Volodymyr; Mishyna, MarynaItem The level of the macroelement calcium under the conditions of the influence of a hypercaloric diet on the pancreas of experimental animal(2023) Kovaltsova, Maryna; Myroshnychenko, Mykhailo; Sirenko, Viktor; Boiko, I.; Sliusarenko, D.; Huliieva, V.; Buha, V.