Наукові праці. Кафедра загальної та клінічної патофізіології імені Д.О. Альперна
Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/1563
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Item The impact of external positive motivation for obtaining education among students of a medical university(2023) Myroshnychenko, Mykhailo; Kuznetsova, Milena; Bibichenko, Viktoria; Myroshnychenko, SerhiiItem Ethical aspects of conducting research: point of view of medical university students(2023) Topoliuk, Kateryna; Tsymbal, Maryna; Myroshnychenko, MykhailoItem Reactive oxygen species generation by blood leucocytes of rats with polycystic ovary syndrome under the conditions of intermittent cold exposure(2023) Zhulikova, Maryna; Myroshnychenko, Mykhailo; Nakonechna, Oksana; Zhulikov, Oleh; Pustova, Nataliia; Bibichenko, Viktoriia; Lytvynenko, Olena; Kucheriavchenko, MarynaThe aim of this study was to determine the level of ROS production by blood leukocytes of rats with PCOS under the conditions of intermittent cold exposure. Materials and methods: In the study, 40 immature female rats of the WAG population at the age of 27 days with a body weight of 80-90 g were used. Five groups were formed (8 animals in each group). Group 1 was represented by intact rats that were not subjected to any manipulations. Group 2 was represented by rats that were injected subcutaneously with 0.2 ml of purified and sterilized olive oil daily for 25 days. Group 3 was represented by rats that were exposed to intermittent cold for 25 days. Group 4 was represented by rats that were modeled with PCOS. Group 5 was represented by rats, which were simulated PCOS against the background of intermittent cold exposure. ROS production was estimated in leukocytes isolated from rats of all groups by flow cytometry using the fluorescent probe of 2,7-dichlorodihydrofluorescein diacetate (H2DCFDA). Results: The experimental study revealed an intracellular excessive production of ROS by leukocytes in rats with polycystic ovary syndrome. The use of intermittent cold exposure normalized the production of reactive oxygen species by leukocytes in rats with polycystic ovary syndrome. Conclusions: The effectiveness of intermittent cold exposure, proven by the authors, allows recommending its use as one of the methods of prevention and treatment of the polycystic ovary syndrome.Item Scientific research in higher medical education institutions through the prism of war: ethical dimension(2023) Myroshnychenko, Mykhailo; Lazurenko, Viktoriya; Kapustnyk, Nataliia; Pasiyeshvili, Nana; Markovskyi, Volodymyr; Mishyna, MarynaItem The level of the macroelement calcium under the conditions of the influence of a hypercaloric diet on the pancreas of experimental animal(2023) Kovaltsova, Maryna; Myroshnychenko, Mykhailo; Sirenko, Viktor; Boiko, I.; Sliusarenko, D.; Huliieva, V.; Buha, V.Item Urogenital inflammatory diseases in women of reproductive age as a cause of an unhealthy start of children`s life: Ukrainian and European research(2023) Myroshnychenko, Mykhailo; Mishyna, Maryna; Mishyn, Yurii; Mozgova, Yuliya; Marchenko, IrynaMaternal and child health is the most important medical and social problem in the world. Modern scientific research of the world leading specialists has shown that fetus and newborn adaptive reserves depend to a greater extent on case of maternal diseases during pregnancy, especially infectious diseases, which can definitely lead to pathology of various organs and systems in fetus, defects in immune response, metabolic problems and affect life expectancy. Maternal infectious-inflammatory process in genitourinary system can act as one of the factors that damages embryogenesis of kidneys at organ, tissue and subcellular levels. Studies have shown an increase in case number of kidneys and urinary tract congenital abnormalities among children exposed to such mathernal pathology in utero. The results of Ukranian and European research indicate that chronic inflammatory diseases of mother genitourinary system are a damaging factor that leads to development of kidney pathology in children at various stages of ontogenesis. In order to prevent the development of nephropathology in children, it is absolutely necessary to carry out, firstly, measures directed to prevent the development of urogenital inflammatory diseases in women of reproductive age, and secondly, in-time detection and treatment of the specified pathology in this category of persons. Thus, the presence of chronic inflammatory diseases of the genitourinary system i pregnant woman is an unfavourable background in course of pregnancy, on which the possibilities of adaptative mechanisms are reduced or limited, various complications of pregnancy arise and fetus kidneys morpho-functional state changes. And this in future will lead to development of various kidney pathologies.Item Chronic inflammatory processes of the maternal genitourinary system, its role in cardiovascular diseases development in their children: Ukrainian and European experience of prevention as the key to the health of future generations(2023) Olianych, Serhii; Myroshnychenko, Mykhailo; Pasiyeshvili, Nana; Kapustnyk, Nataliia; Bibichenko, VictoriaCardiovascular diseases (CVDs) remain the leading cause of morbidity in the world. The burden of CVDs continues to increase over the past decade in almost all countries of the world. The prevalence of CVDs in the world has almost doubled from 271 million i 1990 to 523 million in 2019. The number of deaths from CVDs over the same period has increased by twofold from 12.1 million to 18.6 million. The indicators of years of life with disability and lost years also doubled in total from 17.7 million in 1990 to 34.4 million in 2019. Data from Ukrainian and European statistics testify to the need for timely active measures aimed at preventing the development of CVDs. Modern strategies for the prevention of CVDs are primarily aimed at correcting the known risk factors: quitting smoking, regular physical exercise, normalizing body mass index, glucose, normalizing blood pressure, etc. What is not taken into account in this strategy? The very first periods of a human life, which significantly program health, duration and quality of life, remain beyond attention. In the structure of genital and extragenital pathology of women of reproductive age, significant parts are inflammatory diseases of the genitourinary system, which are characterized by predominantly chronic course. Simultaneous development of inflammatory diseases of the urinary and reproductive systems is explained by the facts that these systems organs develop from one primary germ layer (mesoderm), they have a close anatomical-physiological connection, a common blood supply and lymphatic system, and are also target organs of sex hormones activity. Babies born prematurely are at a greater risk of developing heart failure later in life. The incidence of heart failure in individuals born extremely prematurely (less than 28 weeks gestation) was 17.0 times higher compared to those born at term (37 weeks or more), after taking into account other factors. Similarly, those born very prematurely (28 to 31 weeks gestation) had an incidence of heart failure 3.58 times higher compared to term births. The analysis of the research results of Ukrainian and European scientists has shown that chronic inflammatory processes of the genitourinary system of the mother are a significant damaging factor that can change the morphological and functional state of the fetal and newborn cardiovascular system and cause the development of CVDs at various stages of ontogenesis. Thus, chronic inflammatory processes of the mother's genitourinary system are one of the factors that can cause the development of CVDs in children at different stages of ontogenesis. The classic concept of CVDs prevention should be supplemented taking into account the programming effect of harmful factors that act on the preconception and prenatal stages and reliably increase the risk of CDVs development. Among the reproduktive age, it is extremely necessary to carry out measures aimed at prevention, timely diagnostics and treatment of infectious and inflammatory diseases of the genitourinary system.