Наукові праці. Кафедра фізіології
Permanent URI for this collectionhttps://repo.knmu.edu.ua/handle/123456789/1394
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Item Stress and stress resistance(2023-11) Isaieva, Inna; Karmazina, Iryna; Alekseienko, Roman; Cherniakova, OleksandraIn the modern world, a person at different age of life encounters unexpected situations, usually stressful, which require adequate and urgent mastery, increasing the ability to resist such influences without harm to health. Prolonged physical and psychological exertion that exceeds the norm leads to disruption of the functioning of individual organs and serious diseases. Stress affects a person's behavior, performance, health, relationships with others and in the family. Stress affects a person's behavior, performance, health, relationships with others and in the family. Stress, first of all, is defined as an individual complex of protective reactions of the human body to various adverse factors: emotions, external circumstances and influences, which helps to adapt to frequently changing conditions.Item Impact of stress of the functioning of the cardiovascular, respiratory systems and cardiorespiratory coupling(2023-11) Isaieva, Inna; Karmazina, Iryna; Cherniakova, OleksandraThe analysis of causal relationships between dynamical systems is increasingly of interest in various fields of science. The cardiovascular and respiratory systems are characterized by a complex interaction of several linear and nonlinear subsystems. It is well known that the circulatory and respiratory regulatory systems are combined, that is, the heart and respiratory rhythms are synchronized. The study of cardiopulmonary coupling is still a topical issue for the diagnosis and treatment of certain diseases and for public health in general.Item Bronchospasm management(НФаУ, 2023-03-16) Isaieva, Inna; Karmazina, Iryna; Vakulenko, Alina; Rashchupkina, ZinaidaA bronchospasm is a condition when the smooth muscles of the airways constrict, which results in narrowing of bronchial lumen thus reducing airflow by 15% or more. This limits the amount of inhaled oxygen and exhaled carbon dioxide. Bronchospasm is a common symptom of bronchial asthma and allergies. Among other causes of bronchospasm are the following: chronic obstructive pulmonary disorder, emphysema, chronic bronchitis, lungs and bronchi infections, smoking (including electronic cigarettes), air pollution, smoke inhalation from a fire, allergens of environment (pet dander, dust, pollen), some food chemicals and additives, cleaning chemicals, cold weather, exercise, general anesthesia (causing airways irritation) and some drugs such as blood-thinning medications and NSAIDs (Jeffrey J. Fredberg, 2004). Results of scientific researches have shown that bronchospasm was also associated with atopic rhinitis (Laura Kwiatkowski, Jessica Mitchell, 2016).Item Physiological reasoning of gastric secretion normalization(НФаУ, 2023-03-16) Isaieva, Inna; Karmazina, Iryna; Hromko, YevheniiaThe stomach is a part of the GIT providing several functions such as a chyme formation, synthesis of intrinsic factor for vitamin B12 absorption, microbial protection, and it initiates the reflex of peristalsis. However, stomach does not promote nutrients absorption. Gastric secretion is controlled by autonomic nervous system and neurohormonal agents (gastrin, HCl acid, bicarbonate, etc.) The aim of the study is to summarize the effects of the drugs normalizing gastric acidity based on physiological mechanisms of regulation of gastric secretion.Item Physiological mechanism of respiratory sinus arrhythmia(Харківський національний медичний університет, 2021) Isaieva, Inna; Karmazina, Iryna; Hryhorenko, NadiyaRespiratory sinus arrhythmia determines cardiac vagal tone and characterizes patterns of autonomic modulation of cardiovascular control.Item Diagnostic markers of the cardiorespiratory coupling efficiency(2021-05-07) Isaieva, Inna; Hrygorenko, Nadiya; Karmazina, Iryna; Ivanenko, Olha; Andruckaya, Iryna; Zoabi, KosaiIdentification and establishment of diagnostic markers of cardiorespiratory integration is the one of the main clinical and physiological interests, especially for understanding the mechanisms of adaptation of the organism to environmental changes (hypoxia, hypercapnia, etc.), in various types of training of athletes, and in many diseases.Item Regarding the development of adaptation to psychic and emotional stress depending on the physical training in female medical students(2021-05-16) Marakushyn, Dmytro; Chernobai, Larysa; Karmazina, Iryna; Isaieva, Inna; Hloba, NataliiaThe adaptation of training stress largely depends on the processes of brain integrative activity thus, their study becomes important and perspective for the creation of scientifically based actions aimed at reduction of negative influence of the mentioned factors. Moreover, in the development of compensatory-adaptive reactions the huge role belongs to reactions of cardiovascular system, as its state determines both the short-term and the long-lasting adaptation to environment. That system is the main indicator of all processes ongoing in the human organismThe leading role in development of adaptation to psychic-emotional load belongs to the initial level of intellectual working ability that is based on the expression of asymmetry of hemispheres. 2) The physical training is one of the factors that facilitate the development of adaptation to the stress of studies. 3) The adaptation to constantly increasing psychic-emotional loads in the dynamics of training in medical university is provided by more economical functional changes of activity of cardiovascular system of sports students comparing to the students of general group.Item Peculiarities of adaptive mechanisms in young people with different chronotype(2020-05) Vaschuk, Mykola; Chernobay, Larysa; Isaieva, Inna; Karmazina, Iryna; Somkina, Elizaveta; Suprunova, VeronikaSeveral physiological functions, including body temperature, sleep, physical activity, mood, and cognition are controlled by circadian clock genes, and abnormal circadian rhythms are associated with the development of lifestyle-related diseases. In our research the adaptive capabilities of the body and a causal relationship of circadian rhythm disturbances depending on the person’s chronotype in case of changing time zones have been investigated. An activation of adaptive mechanisms due to increased heart rate, respiratory rate and increased index of Kerdo have been revealed under sharp change in climate and time zones with the most pronounced changes in the group of people with a predominant activity in the evening hours; they required longer time to adapt and return to their previous mode, and thus showing higher risk of pathological desynchronosis development, but persons with an intermediate chronotype have the least violations, which indicates sufficient level of adaptive capabilities of the body.Item Autonomic supply of physical activity in young people with arterial hypotension(2020-02) Marakushyn, Dmytro; Chernobay, Larysa; Isaieva, Inna; Karmazina, Iryna; Goncharova, Аlina; Shenger, Svitlana; Bulynina, Oksana; Sokol, OlenaTotally 128 young people aged 17–21 were examined including 50 individuals with normal values of blood pressure and 78 people with arterial hypotension. Young people with arterial hypotension were ranged according to the level of arteral pressure: first group included 39 persons (moderate arterial hypotension) where the level of mean arterial pressure was determined as 80–75 mm Hg; the second group (expressed arterial hypotension) included 39 people with level of mean arterial pressure 74.9–70 mm Hg followed by an analysis of the nature of the adaptive capacity of cardiovascular system to exercise and in the recovery period.Item Effectiveness of glucocorticoids use in patients with SARS-COV-2(2020-08) Marakushyn, Dmytro; Chernobay, Larysa; Isaieva, Inna; Karmazina, Iryna; Kosai, ZoabiThe purpose of our research was to summarize the current evidence of the effectiveness of glucocorticoid therapy for patients with SARS-COV-2. In our review, we have mentioned the principal mechanisms of corticosteroids action and their roles in suppression of immune response in patients with COVID-19. The research was done using available sources including). 15 were chosen concerning the topic of research. In conclusion, glucocorticoid therapy may increase the risk of death in patients with coronavirus infections who have mild symptoms but still no association found between glucocorticoids and mortality in patients with severe symptoms.Based on the data of researches, short-term and low dose systemic glucocorticoid therapy may be acceptable. But a step forward should be represented by the results of the researched, showing a reduction of death risk for patients on ventilators and on oxygen therapy treated with low dose of glucocorticoids. Currently, the use of immunosuppressants is considered reasonable, despite the risk of adverse events and delayed viral clearance, where the resolution of respiratory failure is the biggest problem in phases IIb and III of COVID-19 patients with the lack of drugs to be effective in such patients.